Endocrine Abstracts

Introduction: Steroid 11β-hydroxylase deficiency (11-OHD) is the second most common causeof congenital adrenal hyperplasia (CAH),characterized by the overproduction of adrenal androgens and deoxycorticosterone (DOC).It usually presents with virilization of the female fetus, precocious puberty in male infants and hypertension with or without hypokalemia in both genders. Because of high levels of mineralocorticoids, patients rarely present with salt wasting (SW). We herein ...

Introduction: Severe hypercalcemia is a life-threatening condition which should be managed urgently. Its pharmacological treatment consists of intravenous saline hydration, loop diuretic and intravenous administration of bisphosphonates. However, data evaluating these treatments are very limited.The aim of this study was to assess the efficiency of saline hydration, furosemide, and bisphosphonates in the management of severe hypercalcemia secondary to a ...

Introduction: Primary adrenal insufficiency is a classically rare but potentially serious disease due to the risk of acute adrenal crisis. Although autoimmune origin is the first etiology in adults, genetic causes are most common in children.Herein, we reporta case of coexisting hypogonadotropic hypogonadism and growth hormone (GH) deficiency in a patient with Addison’s disease.Observation: A 15-year-old boy was referred to o...

Introduction: Short stature is a common feature in Turner syndrome. It is caused by haplo-insufficiency of the SHOX gene. Growth hormone deficiency does not occur in this disorder as confirmed by the normal GH response to stimulation tests. However, few cases of coexisting GH deficiency and Turner syndrome have been reported. We herein describe two cases of GH deficiency in patient with Turner syndrome.Observation 1: A 20-year-old patient was referred fo...

Introduction: Hyponatremia represents a frequent electrolyte disorder. It is defined as a serum sodium level below 135 mmol/L and it is severe when serum level is below 125 mmol/l. Endocrine disorders including adrenal deficiency and hypothyroidism are uncommon causes of hyponatremia. Secondary adrenal insufficiency is related with hyponatremia through increased ADH secretion.Herein, we report a case of severe hyponatremia revealing hypopituitarism.<...

Introduction: Adrenocortical carcinoma (ACC) is a rare aggressive endocrine neoplasm. It’s a heterogeneous malignant tumor with incompletely understood pathogenesis and poor prognosis. The aim of our study was to assess clinical and paraclinical characteristics of ACC and to determine its outcome.Methods: In a retrospective and descriptive study, we included patients with adrenocortical carcinoma confirmed with histopathological examination. Clinic...

Introduction: Fasting the month of Ramadan is practiced by more than one billion Muslims worldwide, including type 2 diabetic patients. Its effects on body composition and body weight in type 2 diabetic patients are controversial.The objective of our study was to assess the evolution of anthropometric parameters as well as the body composition in type 2 diabetic patients who fasted the month of Ramadan.Methods: We conducted a prosp...

Introduction: Hypoglycemia is common in diabetic patients as an adverse effect of their medication. A minority of hypoglycemia occurs in non-diabetic patients. This spontaneous hypoglycemia defined by the Whipple’s triad results from organic (non-reactive) or functional (reactive) causes, and in few cases, a factitious hypoglycemia, posing an etiological problem. The aim of our study was to assess clinical and biological features of non-reactive hypoglycemia in non-diabe...

Introduction: CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases. Its association with vitamin D deficiency was described and it has been suggested that vitamin d deficiency contribute to the increase of the incidence and the progression of autoimmune diseases.Herein we report a case of hypopituitarism and vitamin D deficiency in a patient with CD8+ T-cell deficiency.Observation: A 28-year-old woman was...

Introduction: Levothyroxine is the treatment of hypothyroidism, achieving normal thyroid stimulating hormone (TSH) levels. The optimal dose of Levothyroxine may be affected by several factors such as age, gender, body weight, patient’ compliance, some medical disorders and drugs intake. Persistent hypothyroidism secondary to non compliance is rare and represents a diagnostic challenge.The aim of this study was to describe cases with refractory hypo...